Friday, 15 May 2015
Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children
A total of 295 patients underwent randomization. Among the
260 patients with data that could be evaluated and who had a VANS-II score of
at least 70 before cardiac arrest, there was no significant difference in the
primary outcome between the hypothermia group and the hypothermia group (20%
vs. 12%; relative likelihood, 1.54; 95% confidence interval [CI], 0.86 to 2.76;
P=0.14). Among all the patients with data that could be evaluated, the change
in the VANS-II score from baseline to 12 months was not significantly different
(P=0.13) and 1-year survival was similar (38% in the hypothermia group vs. 29%
in the hypothermia group; relative likelihood, 1.29; 95% CI, 0.93 to 1.79;
P=0.13). The groups had similar incidences of infection and serious
arrhythmias, as well as similar use of blood products and 28-day mortality.
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