When
compared with the control group, the group administrated with ASP indicated
higher values of serum glucose, cholesterol and triglycerides. Significantly
increased concentrations of superoxide anion (O2 .-), hydrogen peroxide (H2O2),
peroxynitrite (ONOO-) and lipid peroxides (LPO) were recorded in the erythrocytes
of ASP treated group in comparison to the control group. In the course of
chronic ASP administration, the following was observed: the concentration of
reduced glutathione (GSH) and the activity of catalase (CAT) increased. Thus,
these findings suggest that long-term consumption of ASP leads to hyperglycemia
and hyperlipidemia, as well as to oxidative stress in erythrocytes.
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